Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment

被引：35

作者：

Chen, SH ^{[1
]}

Pearson, A

Coen, DM

Chen, SH ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan 70101, Taiwan

[2] Harvard Univ, Sch Med, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA

来源：

JOURNAL OF VIROLOGY | 2004年 / 78卷 / 01期

关键词：

D O I：

10.1128/JVI.78.1.520-523.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate.

引用

页码：520 / 523

页数：4

共 34 条

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