Characterisation of the 5-HT receptor potentiating neurotransmission in rabbit bladder

被引：19

作者：

Barras, M ^{[1
]}

VanderGraaf, PH ^{[1
]}

Angel, I ^{[1
]}

机构：

[1] SYNTHELABO RECH LERS,DEPT INTERNAL MED,F-92500 RUEIL MALMAISON,FRANCE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1996年 / 318卷 / 2-3期

关键词：

5-HT; (5-hydroxytryptamine; serotonin); 5-HT3; receptor; urinary bladder; electrical field stimulation; (rabbit);

D O I：

10.1016/S0014-2999(96)00895-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have investigated the effects of 5-hydroxytryptamine (5-HT) on electrically induced contractions of rabbit isolated bladder. Electrical field stimulation evoked twitch contractions which were potentiated by 5-HT (0.3-10 mu M). The potentiating effect of 5-HT was inhibited by ondansetron (pA(2) 9.2) and granisetron (pA(2) 9.1) but not by methysergide or SE 204070 ((1 -butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxan-5-carboxylate hydrochloride). This suggests that the potentiating effect of micromolar concentrations of 5-HT on neuromuscular transmission in rabbit isolated bladder is mediated by 5-HT3 receptors. The receptors involved in the response to lower concentrations of 5-HT, observed in some tissues, remain to be characterised.

引用

页码：425 / 428

页数：4

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