Methamphetamine and AIDS:: 1HMRS studies in a feline model of human disease

被引：9

作者：

Cloak, CC

Chang, L

Ernst, T

Barr, MC

Huitron-Resendiz, S

Sanchez-Alavez, M

Phillips, TR

Henriksen, S

机构：

[1] Brookhaven Natl Lab, Dept Med, Upton, NY USA

[2] Vaccine Res Inst, San Diego, CA USA

[3] Scripps Res Inst, La Jolla, CA USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2004年 / 147卷 / 1-2期

关键词：

HIV; FIV; methamphetamine; proton MRS; white matter;

D O I：

10.1016/j.jneuroim.2003.10.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Potential interactions between psychostimulant drugs and infection with feline immunodeficiency virus (FIV) on brain metabolism were evaluated. Four groups of cats were studied: control, FIV positive, methamphetamine (MA) exposed, and FIV positive plus MA exposed. Frontal gray matter, frontal white matter, and caudate brain extracts were studied with proton magnetic resonance spectroscopy ((HMRS)-H-1). In the frontal white matter, FIV-infected cats showed decreases in creatine and choline, while MA-treated cats had elevated gamma-aminobutyric acid (GABA). The decreased glutamate in FIV cats normalized with MA exposure. FIV and MA both affect brain metabolites individually and combined. (HMRS)-H-1 is useful for evaluating the effects of FIV and drug abuse in the brain. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：16 / 20

页数：5

共 19 条

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