Changes in vascularization in substantia nigra pars compacta of monkeys rendered parkinsonian

被引:81
作者
Barcia, C
Bautista, V
Sánchez-Bahillo, A
Fernández-Villalba, E
Faucheux, B
Poza, MPY
Barreiro, AF
Hirsch, EC
Herrero, MT
机构
[1] Univ Murcia, Sch Med, Dept Human Anat & Psychobiol, Expt Neurol & Neurosurg Grp, E-30071 Murcia, Spain
[2] Hop La Pitie Salpetriere, INSERM, U289, Paris, France
关键词
Parkinson's disease; MPTP; brain inflammation;
D O I
10.1007/s00702-004-0256-2
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The degeneration of nigral dopaminergic neurons in Parkinson's disease is believed to be associated with a glial reaction and inflammatory changes. In turn, local factors may induce changes in vascularization and contribute to neuronal vulnerability. Among these factors, Vascular Endothelial Growth Factor (VEGF) is released in adults under pathological conditions and is thought to induce angiogenesis. In order to determine whether changes in brain vasculature are observed in the affected brain regions in parkinsonism, we quantitatively analysed the VEGF-expressing cells and blood vessels in the substantia nigra of monkeys rendered parkinsonian by MPTP injection and compared the results with those obtained in control monkeys. Using stereological methods, we observed an increase in the number of VEGF-expressing neurons and an increase of the number of blood vessels and their volume occupying the substantia nigra pars compacta of monkeys rendered parkinsonian by chronic MPTP intoxication. These changes in vascularization may therefore modify the neuronal availability of blood nutrients, blood cells or toxic substances and neuronal susceptibility to parkinsonism.
引用
收藏
页码:1237 / 1248
页数:12
相关论文
共 52 条
[1]   Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure [J].
Barcia, C ;
Bahillo, AS ;
Fernández-Villalba, E ;
Bautista, V ;
Poza, MPY ;
Fernández-Barreiro, A ;
Hirsch, EC ;
Herrero, MT .
GLIA, 2004, 46 (04) :402-409
[2]   Measurement of motor disability in MPTP-treated macaques using a telemetry system for estimating circadian motor activity [J].
Barcia, C ;
De Pablos, V ;
Bautista-Hernández, V ;
Sanchez-Bahillo, A ;
Fernández-Barreiro, A ;
Poza, M ;
Herrero, MT .
JOURNAL OF NEUROSCIENCE METHODS, 2004, 134 (01) :59-64
[3]   Circadian determinations of cortisol, prolactin and melatonin in chronic methyl-phenyl-tetrahydropyridine-treated monkeys [J].
Barcia, C ;
Bautista, V ;
Sánchez-Bahillo, A ;
Fernández-Villalba, E ;
Navarro-Ruis, JM ;
Barreiro, AF ;
Poza, MPY ;
Herrero, MT .
NEUROENDOCRINOLOGY, 2003, 78 (02) :118-128
[4]   Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling [J].
Beck, H ;
Acker, T ;
Püschel, AW ;
Fujisawa, H ;
Carmeliet, P ;
Plate, KH .
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2002, 61 (04) :339-350
[5]  
BREIER G, 1992, DEVELOPMENT, V114, P521
[6]   DISTRIBUTION WITHIN BRAIN OF FERRITIN INJECTED INTO CEREBROSPINAL FLUID COMPARTMENTS .2. PARENCHYMAL DISTRIBUTION [J].
BRIGHTMAN, MW .
AMERICAN JOURNAL OF ANATOMY, 1965, 117 (02) :193-+
[7]   Angiogenesis in cancer and other diseases [J].
Carmeliet, P ;
Jain, RK .
NATURE, 2000, 407 (6801) :249-257
[8]  
Casper D, 2002, CELL TRANSPLANT, V11, P331
[9]   Expression of hypoxia-inducible factor-1α in the brain of rats during chronic hypoxia [J].
Chávez, JC ;
Agani, F ;
Pichiule, P ;
LaManna, JC .
JOURNAL OF APPLIED PHYSIOLOGY, 2000, 89 (05) :1937-1942
[10]   Paracrine control of vascularization and neurogenesis by neurotrophins [J].
Emanueli, C ;
Schratzberger, P ;
Kirchmair, R ;
Madeddu, P .
BRITISH JOURNAL OF PHARMACOLOGY, 2003, 140 (04) :614-619