NT-proBNP and the anti-inflammatory cytokines are correlated with endothelial progenitor cells' response to cardiac surgery

被引:28
作者
Cesari, Francesca [1 ,2 ]
Caporale, Roberto [4 ]
Marcucci, Rossella [1 ,2 ]
Caciolli, Sabina [3 ]
Stefano, Pier Luigi [3 ]
Capalbo, Andrea [1 ,2 ]
Macchi, Claudio [6 ]
Vannucci, Mauro [5 ]
Gensini, Gian Franco [6 ]
Abbate, Rosanna [1 ,2 ]
Gori, Anna Maria [1 ,2 ]
机构
[1] Univ Florence, Azienda Osped Univ Careggi, Thrombosis Ctr, Dept Med & Surg Crit Care, I-50134 Florence, Italy
[2] Univ Florence, Azienda Osped Univ Careggi, Ctr Study Mol & Clin Level Chron Degenerat & Neop, I-50134 Florence, Italy
[3] Azienda Osped Univ Careggi, Unit Cardiac Surg, Florence, Italy
[4] Azienda Osped Univ Careggi, Cent Lab, Florence, Italy
[5] Unit Cardiol Rehabil IFCA Ulivella Glicini, Florence, Italy
[6] Fdn Don Carlo Gnocchi Onlus IRCCS, Ctr S Maria Agli Ulivi, Florence, Italy
关键词
endothelial progenitor cells; cytochemokines; cardiac surgery; N-terminal pro-brain natriuretic peptide;
D O I
10.1016/j.atherosclerosis.2007.09.045
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: We used cardiac surgery as a model of acute inflammatory response to evaluate the role of the inflammatory mediators in influencing the number of circulating endothelial progenitor cells (EPCs). Methods: In 38 coronary artery by-pass grafting (CABG) [28M/10F] and in 54 valvular [28M/26F] patients the numbers of EPCs and the serum levels of IL-1ra, IL-6, IL-8, IL-10, vascular endothelial growth factor (VEGF), high sensitivity C-reactive protein (hsCRP) and NT-proBNP were determined before (T1), 72 h (T2), and 10 days after cardiac intervention (T3). Peripheral blood EPCs were measured by flow cytometric analysis and were defined as CD34+KDR+, CD133+KDR+ and CD34+CD133+KDR+. Results: We demonstrate that the cardiac surgery reduces, 72 h after intervention, the number of all the three types of EPCs with a contemporary marked increase of pro-inflammatory and anti -inflammatory cytokines and NT-proBNP levels. At baseline, EPC number was inversely related with age. At multiple linear regression analysis, after adjusting for age, cardiovascular risk factors and medications, age and IL-8 serum levels were significantly related to EPC number. At T2, an inverse relationship between NT-proBNP and the number of EPCs was found in the whole study population. At T3, 10 days after the intervention, at multivariate linear regression analysis, IL-10 and IL-1ra serum levels were significantly and positively associated with EPC number. Conclusions: This study provides new insights into the relationship between inflammatory activation and mobilisation of EPCs in patients underwent cardiac surgery, by showing that NT-ProBNP and cytochemokines mediate the EPC changes in acute and post-acute response to the inflammatory stimulus of intervention. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:138 / 146
页数:9
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