Cancer-related inflammation: Common themes and therapeutic opportunities

被引：527

作者：

Balkwill, Frances R. ^{[1
]}

Mantovani, Alberto ^{[2
]}

机构：

[1] Queen Mary Univ London, Ctr Canc & Inflammat, Barts Canc Inst, Barts & London Sch Med & Dent, London EC1M 6BQ, England

[2] Univ Milan, Ist Clin Humanitas IRCCS, I-20089 Milan, Italy

来源：

SEMINARS IN CANCER BIOLOGY | 2012年 / 22卷 / 01期

关键词：

Inflammation; Macrophages; Cytokines; Chemokines; Tumor microenvironment; TUMOR-NECROSIS-FACTOR; CD4(+) T-CELLS; FACTOR-ALPHA; ANGIOGENIC SWITCH; PROGENITOR CELLS; PROSTATE-CANCER; TNF-ALPHA; KAPPA-B; INTERLEUKIN-6; MACROPHAGES;

D O I：

10.1016/j.semcancer.2011.12.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Inflammatory cells and mediators are an essential component of the tumor microenvironment. Inflammatory circuits can differ considerably in different tumors in terms of cellular and cytokine networks and molecular drivers. However, macrophages are a common and fundamental component of cancer promoting inflammation. Drivers of macrophage functional orientation include tumor cells, cancer-associated fibroblasts. T cells and B cells. Dissection of the diversity of cancer-related inflammation is instrumental to the design of therapeutic approaches that target cancer-related inflammation. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：33 / 40

页数：8

共 105 条

[1] Tumor Necrosis Factor Receptor Expression and Signaling in Renal Cell Carcinoma [J].

Al-Lamki, Rafia S. ;

Sadler, Timothy J. ;

Wang, Jun ;

Reid, Martin J. ;

Warren, Anne Y. ;

Movassagh, Mehregan ;

Lu, Wanhua ;

Mills, Ian G. ;

Neal, David E. ;

Burge, Johanna ;

Vandenebeele, Peter ;

Pober, Jordan S. ;

Bradley, John R. .

AMERICAN JOURNAL OF PATHOLOGY, 2010, 177 (02) :943-954

[2] B-cell-derived lymphotoxin promotes castration-resistant prostate cancer [J].

Ammirante, Massimo ;

Luo, Jun-Li ;

Grivennikov, Sergei ;

Nedospasov, Sergei ;

Karin, Michael .

NATURE, 2010, 464 (7286) :302-U187

[3] Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis [J].

Ancrile, Brooke ;

Lim, Kian-Huat ;

Counter, Christopher M. .

GENES & DEVELOPMENT, 2007, 21 (14) :1714-1719

[4] Tumor necrosis factor-α in the pathogenesis and treatment of cancer [J].

Anderson, GM ;

Nakada, MT ;

DeWitte, M .

CURRENT OPINION IN PHARMACOLOGY, 2004, 4 (04) :314-320

[5] FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis [J].

Andreu, Pauline ;

Johansson, Magnus ;

Affara, Nesrine I. ;

Pucci, Ferdinando ;

Tan, Tingting ;

Junankar, Simon ;

Korets, Lidiya ;

Lam, Julia ;

Tawfik, David ;

DeNardo, David G. ;

Naldini, Luigi ;

de Visser, Karin E. ;

De Palma, Michele ;

Coussens, Lisa M. .

CANCER CELL, 2010, 17 (02) :121-134

[6] IL6-STAT3-HIF Signaling and Therapeutic Response to the Angiogenesis Inhibitor Sunitinib in Ovarian Clear Cell Cancer [J].

Anglesio, Michael S. ;

George, Joshy ;

Kulbe, Hagen ;

Friedlander, Michael ;

Rischin, Danny ;

Lemech, Charlotte ;

Power, Jeremy ;

Coward, Jermaine ;

Cowin, Prue A. ;

House, Colin M. ;

Chakravarty, Probir ;

Gorringe, Kylie L. ;

Campbell, Ian G. ;

Okamoto, Aikou ;

Birrer, Michael J. ;

Huntsman, David G. ;

de Fazio, Anna ;

Kalloger, Steve E. ;

Balkwill, Frances ;

Gilks, C. Blake ;

Bowtell, David D. .

CLINICAL CANCER RESEARCH, 2011, 17 (08) :2538-2548

[7] Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Obeid, Michel ;

Ortiz, Carla ;

Criollo, Alfredo ;

Mignot, Gregoire ;

Maiuri, M. Chiara ;

Ullrich, Evelyn ;

Saulnier, Patrick ;

Yang, Huan ;

Amigorena, Sebastian ;

Ryffel, Bernard ;

Barrat, Franck J. ;

Saftig, Paul ;

Levi, Francis ;

Lidereau, Rosette ;

Nogues, Catherine ;

Mira, Jean-Paul ;

Chompret, Agnes ;

Joulin, Virginie ;

Clavel-Chapelon, Francoise ;

Bourhis, Jean ;

Andre, Fabrice ;

Delaloge, Suzette ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

NATURE MEDICINE, 2007, 13 (09) :1050-1059

[8] Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells [J].

Ara, Tasnim ;

Song, Liping ;

Shimada, Hiroyuki ;

Keshelava, Nino ;

Russell, Heidi V. ;

Metelitsa, Leonid S. ;

Groshen, Susan G. ;

Seeger, Robert C. ;

DeClerck, Yves A. .

CANCER RESEARCH, 2009, 69 (01) :329-337

[9] Malignancy and biologic therapy in rheumatoid arthritis [J].

Askling, Johan ;

Bongartz, Tim .

CURRENT OPINION IN RHEUMATOLOGY, 2008, 20 (03) :334-339

[10] Tumour necrosis factor and cancer [J].

Balkwill, Frances .

NATURE REVIEWS CANCER, 2009, 9 (05) :361-371

← 1 2 3 4 5 6 7 8 9 10 →