Neuroprotective effects of the cyanidin-3-O-β-D-glucopyranoside isolated from mulberry fruit against cerebral ischemia

被引：165

作者：

Kang, TH

Hur, JY

Kim, HB

Ryu, JH

Kim, SY ^{[1
]}

机构：

[1] Kyung Hee Univ, Grad Sch EW Med Sci, Kyunggido 449701, South Korea

[2] Natl Inst Agr Sci & Technol, Rural Dev Adm, Dept Agr Biol, Suwon 441100, South Korea

[3] Kyung Hee Univ, Dept Oriental Pharmaceut Sci, Seoul, South Korea

来源：

NEUROSCIENCE LETTERS | 2006年 / 391卷 / 03期

关键词：

neuroprotection; mulberry fruit extracts (Morus alba L.); cyanidin-3-O-beta-d-glucopyranoside; oxygen glucose deprivation; cerebral ischemia; myeloperoxidase; immunohistochemistry;

D O I：

10.1016/j.neulet.2005.08.053

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study investigated the neuroprotective effects of cyanidin-3-O-beta-D-glucopyranoside (C3G) from the mulberry fruits on neuronal cell damage. A 1% HCl-MeOH mulberry fruit extract was shown to have a cytoprotective effect on PC 12 cells that had been exposed to hydrogen peroxide. The extract inhibited the cerebral ischemic damage caused by oxygen glucose deprivation (OGD) in PC12 cells. The neuroprotective effect of the mulberry fruit extract was further demonstrated in vivo using a mouse-brain-injury model with a transient middle cerebral artery occlusion (MCAO). C3G was isolated as a neuroprotective constituent from the mulberry fruit extract. Compared with the control group, C3G had neuroprotective effects on the PC12 cells exposed to hydrogen peroxide in vitro and on cerebral ischemic damage in vivo. (C) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：122 / 126

页数：5

共 14 条

[1] Polyhydroxylated alkaloids isolated from mulberry trees (Morus alba L.) and silkworms (Bombyx mori L.) [J].