Do cells let-7 determine stemness?

被引：38

作者：

Droge, Peter ^{[1
]}

Davey, Curt A. ^{[2
]}

机构：

[1] Nanyang Technol Univ, Div Genom & Genet, Singapore 637551, Singapore

[2] Nanyang Technol Univ, Sch Biol Sci, Div Struct & Computat Biol, Singapore 637551, Singapore

来源：

CELL STEM CELL | 2008年 / 2卷 / 01期

关键词：

D O I：

10.1016/j.stem.2007.12.003

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

During oncogenic transformation, microRNA levels of the translation-regulatory factor let-7 correlate inversely with expression of the HMGA2 oncoprotein. In a recent issue of Cell, Yu et al. (2007) now provide evidence that the let-7/HMGA2 linkage could be a signature of cancer stem cells in vivo, with broader implications for stem cell research.

引用

页码：8 / 9

页数：2

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