Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system

被引：147

作者：

Kogure, Kentaro ^{[1
]}

Akita, Hidetaka ^{[1
]}

Yamada, Yuma ^{[1
]}

Harashima, Hideyoshi ^{[1
]}

机构：

[1] Hokkaido Univ, Fac Pharmaceut Sci, Lab Mol Design Pharmaceut, Sapporo, Hokkaido 0600812, Japan

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2008年 / 60卷 / 4-5期

关键词：

octaarginine; gene delivery; nanoparticle; membrane fusion; nuclear deposition; multifunctional; nano device; Programmed packaging; MEND; siRNA;

D O I：

10.1016/j.addr.2007.10.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this review, we describe a key role of octaarginine (R8) in developing our new concept of "Programmed Packaging", by which we succeeded in creating a multifunctional envelope-type nano device (MEND) as a non-viral gene-delivery system. This concept can be applied not only to nuclear targeting of plasmid DNA (pDNA) but also to cytosolic delivery of functional nucleic acids such as oligonucleotides or siRNA, This concept has been extended to other organelles such as mitochondria as a foundation for innovative nanomedicine. Finally, we discuss the rate-limiting step in gene delivery by comparing non-viral and viral gene delivery systems, which clearly indicates the importance of nuclear disposition of pDNA for efficient transfection. (C) 2007 Elsevier B.V. All rights reserved.

引用

收藏

页码：559 / 571

页数：13

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