Exhaled breath condensate pH in patients with lung cancer

被引：10

作者：

Antus, Balazs ^{[1
,2
]}

Barta, Imre ^{[1
]}

机构：

[1] Natl Koranyi Inst TB & Pulmonol, Dept Pathophysiol, H-1121 Budapest, Hungary

[2] Natl Koranyi Inst TB & Pulmonol, Dept Pulmonol, H-1121 Budapest, Hungary

来源：

LUNG CANCER | 2012年 / 75卷 / 02期

关键词：

Acidification; Biomarker; Breath condensate; Lung cancer; pH; Staging; OBSTRUCTIVE PULMONARY-DISEASE; ASTHMA;

D O I：

10.1016/j.lungcan.2011.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Assessment of exhaled breath condensate (EBC) pH is a promising method for investigating and monitoring airway pathology in a number of lung diseases. In this cross-sectional study we tested whether development of lung cancer is associated with acidification of EBC. EBC was collected in 43 smoking patients with lung cancer (squamous cell carcinoma: 17 patients, adenocarcinoma: 16 patients, and small cell lung cancer: 10 patients) before receiving any anticancer treatment and in 20 healthy smokers without any clinical and radiological evidence of pulmonary tumor. EBC pH was measured by CO2 gas standardization, the most reliable and accurate method at present. EBC pH in patients with pulmonary tumor (6.68 +/- 0.02) and in controls (6.63 +/- 0.05) was similar (p > 0.05). Results were affected neither by the histological subtype nor the stage of the tumors. Our data suggest that assessment of EBC pH is of limited value for the diagnosis and/or screening of lung cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

引用

页码：178 / 180

页数：3

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