Selective silencing of NaV1.7 decreases excitability and conduction in vagal sensory neurons

被引：68

作者：

Muroi, Yukiko

Ru, Fei

Kollarik, Marian

Canning, Brendan J.

Hughes, Stephen A. ^{[2
]}

Walsh, Stacey ^{[3
]}

Sigg, Martin ^{[4
]}

Carr, Michael J. ^{[4
]}

Undem, Bradley J. ^{[1
]}

机构：

[1] Johns Hopkins Univ, Ctr Asthma & Allergy, Baltimore, MD 21224 USA

[2] GlaxoSmithKline, Resp Drug Discovery, Stevenage, Herts, England

[3] GlaxoSmithKline, Discovery & Technol Grp, Mol Discovery Res, Upper Providence, PA USA

[4] GlaxoSmithKline, Resp Drug Discovery, King Of Prussia, PA USA

来源：

JOURNAL OF PHYSIOLOGY-LONDON | 2011年 / 589卷 / 23期

基金：

美国国家卫生研究院;

关键词：

GATED SODIUM-CHANNELS; TETRODOTOXIN; PHARMACOLOGY;

D O I：

10.1113/jphysiol.2011.215384

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Non-technical summary Sodium channels are obligatory for the conduction of action potentials along axons. There are several different sodium channel subtypes expressed in vagal sensory neurons, and it is difficult to pharmacologically block these subtypes selectively. We used virally delivered shRNA to selectively block the production of one of the sodium channel subtypes expressed in vagal sensory neurons, namely NaV1.7, and found that by selectively inhibiting the expression of this channel the conduction of action potentials was blocked in the majority of vagal sensory neurons. This study also shows that NaV1.7 is required for the elicitation of classical vagal reflexes such as cough.

引用

收藏

页码：5663 / 5676

页数：14

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