When versatility matters: activins/inhibins as key regulators of immunity

被引：62

作者：

Aleman-Muench, G. R. ^{[1
]}

Soldevila, G. ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Immunol, Mexico City 04510, DF, Mexico

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2012年 / 90卷 / 02期

关键词：

activin; inhibin; inflammation; immune cells; immunity; tolerance; GROWTH-FACTOR-BETA; INHIBIN-DEFICIENT MICE; ERYTHROID-DIFFERENTIATION FACTOR; MOUSE PERITONEAL-MACROPHAGES; MARROW STROMAL FIBROBLASTS; T-CELL DEVELOPMENT; ACTIVIN-A RELEASE; TGF-BETA; IN-VITRO; SIGNALING PATHWAYS;

D O I：

10.1038/icb.2011.32

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Activins and inhibins are members of the transforming growth factor-beta superfamily that have been considered crucial regulators of cell processes, such as differentiation, proliferation and apoptosis, in different cell types. Initial studies about the function of activin A in the immune system focused on the regulation of hematopoiesis in the bone marrow under homeostatic and inflammatory conditions. Recent data provide a more comprehensive understanding about the role of activins/inhibins in the immune system. Novel findings included in this review point out the important requirement of activin/inhibin signaling to maintain the balance between homeostatic and inflammatory signals that are required for the optimal development and function of immune cells. The purpose of this review is to highlight the versatile nature of activins/inhibins as key regulators of both the innate and adaptive immune responses. Immunology and Cell Biology (2012) 90, 137-148; doi:10.1038/icb.2011.32; published online 3 May 2011

引用

页码：137 / 148

页数：12

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