Reduced COMT activity as a possible environmental risk factor for breast cancer. Opinion.

被引：7

作者：

Creveling, CR ^{[1
]}

机构：

[1] NIDDK, Chem Lab, NIH, Bethesda, MD 20814 USA

来源：

NEUROTOXICITY RESEARCH | 2003年 / 5卷 / 07期

关键词：

catechol-O-methyltransferase; breast cancer; catechol estrogens; isoflavenoids; polyphenols; vitamin D;

D O I：

10.1007/BF03033157

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent genetic epidemiological studies implicate a low activity form of catechol-O-methyltransferase (COMT) with increased risk factor for breast cancer. Taking into account, the role of COMT in the metabolism of otherwise carcinogenic catecholestrogens, it is reasonable to propose that environmental or dietary products that inhibit COMT pose a risk for breast cancer.

引用

页码：473 / 474

页数：2

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