An abundance of bacterial ADP-ribosyltransferases - implications for the origin of exotoxins and their human homologues

被引：51

作者：

Pallen, MJ ^{[1
]}

Lam, AC

Loman, NJ

McBride, A

机构：

[1] Univ Birmingham, Div Immun & Infect, Microbial Genomics & Pathogenesis Unit, Sch Med, Birmingham B15 2TT, W Midlands, England

[2] Queens Univ Belfast, Dept Microbiol & Immunobiol, Belfast BT12 6BN, Antrim, North Ireland

来源：

TRENDS IN MICROBIOLOGY | 2001年 / 9卷 / 07期

关键词：

D O I：

10.1016/S0966-842X(01)02074-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ADP-ribosylation is a post-translational modification that can be seen in many contexts, including as the primary mechanism of action of many important bacterial exotoxins, By data-mining complete and incomplete bacterial genome sequences, we have discovered > 20 novel putative ADP-ribosyltransferases. including several new potential toxins.

引用

页码：302 / 307

页数：6

共 34 条

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