Metal nanoshells as a contrast agent in near-infrared diffuse optical tomography

被引：37

作者：

Wu, CF ^{[1
]}

Liang, XP ^{[1
]}

Jiang, HB ^{[1
]}

机构：

[1] Univ Florida, Dept Biomed Engn, Gainesville, FL 32611 USA

来源：

OPTICS COMMUNICATIONS | 2005年 / 253卷 / 1-3期

基金：

美国国家卫生研究院;

关键词：

nanoshell; optical imaging; contrast agent;

D O I：

10.1016/j.optcom.2005.04.057

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

The plasma resonance peak of metal nanoshells can be tuned to the near-infrared region (700-900 nm), making them have great potential in biological and biomedical applications. Gold nanoshells has been synthesized and characterized as a contrast agent for diffuse optical tomography. A unique advantage of the nanoshells is their tremendous absorptivity. Spectral measurements indicate that the absorption cross-section of each nanoshell is 40,000 times larger than that of an Indocyanine Green (ICG) molecule, suggesting that the nanoshells are a much more efficient absorption agent than ICG molecules. Tissue-like phantom experiments using the nanoshells were performed using our diffuse optical imaging system and absorption images were successfully obtained through a finite element based reconstruction algorithm. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：214 / 221

页数：8

共 32 条

[1] Sources of absorption and scattering contrast for near-infrared optical mammography [J].

Cerussi, AE ;

Berger, AJ ;

Bevilacqua, F ;

Shah, N ;

Jakubowski, D ;

Butler, J ;

Holcombe, RF ;

Tromberg, BJ .

ACADEMIC RADIOLOGY, 2001, 8 (03) :211-218

[2] Near-infrared (NIR) optical spectroscopy characterizes breast tissue hormonal and age status [J].

Chance, B .

ACADEMIC RADIOLOGY, 2001, 8 (03) :209-210

[3] Gold nanocages: Bioconjugation and their potential use as optical imaging contrast agents [J].

Chen, J ;

Saeki, F ;

Wiley, BJ ;

Cang, H ;

Cobb, MJ ;

Li, ZY ;

Au, L ;

Zhang, H ;

Kimmey, MB ;

Li, XD ;

Xia, YN .

NANO LETTERS, 2005, 5 (03) :473-477

[4] Metabolism-enhanced tumor localization by fluorescence imaging:: in vivo animal studies [J].

Chen, Y ;

Zheng, G ;

Zhang, ZH ;

Blessington, D ;

Zhang, M ;

Li, H ;

Liu, Q ;

Zhou, L ;

Intes, X ;

Achilefu, S ;

Chance, B .

OPTICS LETTERS, 2003, 28 (21) :2070-2072

[5] PLASMA RESONANCE ENHANCEMENT OF RAMAN-SCATTERING BY PYRIDINE ADSORBED ON SILVER OR GOLD SOL PARTICLES OF SIZE COMPARABLE TO THE EXCITATION WAVELENGTH [J].

CREIGHTON, JA ;

BLATCHFORD, CG ;

ALBRECHT, MG .

JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS II, 1979, 75 :790-798

[6] Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments [J].

Ebert, B ;

Sukowski, U ;

Grosenick, D ;

Wabnitz, H ;

Moesta, TK ;

Licha, K ;

Becker, A ;

Semmler, W ;

Schlag, PM ;

Rinneberg, H .

JOURNAL OF BIOMEDICAL OPTICS, 2001, 6 (02) :134-140

[7] In vivo cancer targeting and imaging with semiconductor quantum dots [J].

Gao, XH ;

Cui, YY ;

Levenson, RM ;

Chung, LWK ;

Nie, SM .

NATURE BIOTECHNOLOGY, 2004, 22 (08) :969-976

[8] Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance [J].

Hirsch, LR ;

Stafford, RJ ;

Bankson, JA ;

Sershen, SR ;

Rivera, B ;

Price, RE ;

Hazle, JD ;

Halas, NJ ;

West, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13549-13554

[9] Quantitative optical image reconstruction of turbid media by use of direct-current measurements [J].

Iftimia, N ;

Jiang, HB .

APPLIED OPTICS, 2000, 39 (28) :5256-5261

[10] A compact, parallel-detection diffuse optical mammography system [J].

Iftimia, N ;

Gu, XJ ;

Xu, Y ;

Jiang, HB .

REVIEW OF SCIENTIFIC INSTRUMENTS, 2003, 74 (05) :2836-2842

← 1 2 3 4 →