The effect of TGF-beta 1 on cell proliferation and proteoglycan production in human melanoma cells depends on the degree of cell differentiation

被引：10

作者：

Heredia, A ^{[1
]}

Villena, J ^{[1
]}

Romaris, M ^{[1
]}

Molist, A ^{[1
]}

Bassols, A ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA,FAC VET,DEPT BIOQUIM & BIOL MOL,BELLATERRA 08193,SPAIN

来源：

CANCER LETTERS | 1996年 / 109卷 / 1-2期

关键词：

proteoglycan; transforming growth factor beta 1; melanoma; differentiation;

D O I：

10.1016/S0304-3835(96)04402-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effect of transforming growth factor beta 1 (TGF-beta 1) on cell proliferation, colony formation in soft agar and synthesis and structure of proteoglycans was studied in three human melanoma cell lines at different stages of differentiation: SK-mel-1.36-1-5 (early), SK-mel-3.44 (intermediate) and SK-mel-23 (late). TGF-beta 1 potently inhibited cell growth in monolayer as well as in soft agar. TGF-beta 1 increased the release of sulfated proteoglycans into the medium, including the cell-specific melanoma proteoglycan, mel-PG, and induced changes in disaccharide composition and sulfation of the glycosaminoglycan chains. In all the cases, the effect of TGF-beta 1 was more pronounced in the most undifferentiated cell line SK-mel-1.36-1-5 than in the SK-mel-3.44, whereas it had no effect on the most differentiated SK-mel-23 cells.

引用

页码：39 / 47

页数：9

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