A role for quorum sensing in regulating innate immune responses mediated by Vibrio cholerae outer membrane vesicles (OMVs)

被引：23

作者：

Bielig, Harald ^{[1
]}

Dongre, Mitesh ^{[2
,3
]}

Zurek, Birte ^{[1
]}

Wai, Sun N. ^{[2
,3
]}

Kufer, Thomas A. ^{[1
]}

机构：

[1] Univ Cologne, Inst Med Microbiol Immunol & Hyg, Cologne, Germany

[2] Umea Univ, Dept Mol Biol, Umea, Sweden

[3] Umea Univ, UCMR, Umea, Sweden

来源：

GUT MICROBES | 2011年 / 2卷 / 05期

基金：

瑞典研究理事会;

关键词：

OMVs; innate immunity; peptidoglycan; NLR; Vibrio cholerae;

D O I：

10.4161/gmic.2.5.18091

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Outer membrane vesicles (OMVs) are released from many Gram-negative bacteria. OMVs interact with and are taken up by human cells. We and others have now showed that OMVs contain peptidoglycan, which is sensed mainly by the pattern-recognition receptor NOD1 in the cytoplasm of host cells. Vibrio cholerae is clinically important as one of the causative agents of severe dehydrating diarrhea in humans. We showed that non-O1 non-O139 V. cholerae (NOVC) strains of V. cholera produce OMVs. Of note, we revealed that NOVC can evade NOD1-mediated immune surveillance by the quorum sensing machinery. Here we review these recent findings and discuss the relevance for our understanding of bacterial infections and innate immune responses.

引用

收藏

页码：274 / 279

页数：6

相关论文

共 48 条

[1]

SEQUENCE AND FUNCTION OF LUXO, A NEGATIVE REGULATOR OF LUMINESCENCE IN VIBRIO-HARVEYI [J].

BASSLER, BL ;

WRIGHT, M ;

SILVERMAN, MR .

MOLECULAR MICROBIOLOGY, 1994, 12 (03) :403-412

[2]

MULTIPLE SIGNALING SYSTEMS CONTROLLING EXPRESSION OF LUMINESCENCE IN VIBRIO-HARVEYI - SEQUENCE AND FUNCTION OF GENES ENCODING A 2ND SENSORY PATHWAY [J].

BASSLER, BL ;

WRIGHT, M ;

SILVERMAN, MR .

MOLECULAR MICROBIOLOGY, 1994, 13 (02) :273-286

[3]

Bielig H, 2011, INFECT IMMUN

[4]

Long-Distance Delivery of Bacterial Virulence Factors by Pseudomonas aeruginosa Outer Membrane Vesicles [J].

Bomberger, Jennifer M. ;

MacEachran, Daniel P. ;

Coutermarsh, Bonita A. ;

Ye, Siying ;

O'Toole, George A. ;

Stanton, Bruce A. .

PLOS PATHOGENS, 2009, 5 (04)

[5]

A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system [J].

Boneca, Ivo G. ;

Dussurget, Olivier ;

Cabanes, Didier ;

Nahori, Marie-Anne ;

Sousa, Sandra ;

Lecuit, Marc ;

Psylinakis, Emmanuel ;

Bouriotis, Vassilis ;

Hugot, Jean-Pierre ;

Giovannini, Marco ;

Coyle, Anthony ;

Bertin, John ;

Namane, Abdelkader ;

Rousselle, Jean-Claude ;

Cayet, Nadege ;

Prevost, Marie-Christine ;

Balloy, Viviane ;

Chignard, Michel ;

Philpottt, Dana J. ;

Cossart, Pascale ;

Girardin, Stephen E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :997-1002

[6]

Comparative antibody-mediated phagocytosis of Staphylococcus epidermidis cells grown in a biofilm or in the planktonic state [J].

Cerca, Nuno ;

Jefferson, Kimberly K. ;

Oliveira, Rosario ;

Pier, Gerald B. ;

Azeredo, Joana .

INFECTION AND IMMUNITY, 2006, 74 (08) :4849-4855

[7]

Chamaillard M, 2003, NAT IMMUNOL, V4, P702, DOI 10.1038/ni945

[8]

Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape [J].

Chaput, Catherine ;

Ecobichon, Chantal ;

Cayet, Nadege ;

Girardin, Stephen E. ;

Werts, Catherine ;

Guadagnini, Stephanie ;

Prevost, Marie-Christine ;

Mengin-Lecreulx, Dominique ;

Labigne, Agnes ;

Boneca, Ivo G. .

PLOS PATHOGENS, 2006, 2 (09) :844-852

[9]

VIBRIO-CHOLERAE WOUND-INFECTION ACQUIRED IN COLORADO [J].

COVER, TL ;

DUNN, BE ;

ELLISON, RT ;

BLASER, MJ .

JOURNAL OF INFECTIOUS DISEASES, 1989, 160 (06) :1083-1083

[10]

Biogenesis of bacterial membrane vesicles [J].

Deatherage, Brooke L. ;

Lara, J. Cano ;

Bergsbaken, Tessa ;

Barrett, Sara L. Rassoulian ;

Lara, Stephanie ;

Cookson, Brad T. .

MOLECULAR MICROBIOLOGY, 2009, 72 (06) :1395-1407

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