Renal effects of cyclooxygenase-2 selective inhibitors

被引：14

作者：

Harris, CJ ^{[1
]}

Brater, DC ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Med, Div Clin Pharmacol, Indianapolis, IN USA

来源：

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2001年 / 10卷 / 05期

关键词：

D O I：

10.1097/00041552-200109000-00009

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Recent in-vitro and animal data show that cyclooxygenase-2 has an integral role in the physiology and pathophysiology of the kidney. Cyclooxygenase-2 regulates renin-angiotensin secretion, and thereby glomerular filtration rate and sodium homeostasis. It is also important for protecting against hypertonic stress. As a consequence, it is not surprising that clinical data verify that selective inhibitors of cyclooxygenase-2 affect renal function to a degree similar to that which has previously been documented with nonselective nonsteroidal anti-inflammatory drugs. Curr Opin Nephrol Hypertens 10:603-610. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：603 / 610

页数：8

共 35 条

[1]

Atta M G, 1997, Am J Ther, V4, P55, DOI 10.1097/00045391-199701000-00011

[2]

Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. [J].

Bombardier, C ;

Laine, L ;

Reicin, A ;

Shapiro, D ;

Burgos-Vargas, R ;

Davis, B ;

Day, R ;

Ferraz, MB ;

Hawkey, CJ ;

Hochberg, MC ;

Kvien, TK ;

Schnitzer, TJ ;

Weaver, A .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (21) :1520-1528

[3]

Brater D. Craig, 1999, American Journal of Medicine, V107, p65S

[4]

Prostaglandin receptors: their role in regulating renal function [J].

Breyer, MD ;

Breyer, RM .

CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2000, 9 (01) :23-29

[5]

Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride [J].

Cheng, HF ;

Wang, JL ;

Zhang, MZ ;

McKanna, JA ;

Harris, RC .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (05) :681-688

[6]

Nitric oxide regulates renal cortical cyclooxygenase-2 expression [J].

Cheng, HF ;

Wang, JL ;

Zhang, MZ ;

McKanna, JA ;

Harris, RC .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2000, 279 (01) :F122-F129

[7]

Crofford LJ, 1997, J RHEUMATOL, V24, P15

[8]

Nonsteroidal anti-inflammatory drugs (NSAIDs) and blood pressure [J].

FierroCarrion, GA ;

Ram, CVS .

AMERICAN JOURNAL OF CARDIOLOGY, 1997, 80 (06) :775-+

[9]

Selective targeting of cyclooxygenase-2 reveals its role in renal medullary interstitial cell survival [J].

Hao, CM ;

Kömhoff, M ;

Guan, YF ;

Redha, R ;

Breyer, MD .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 1999, 277 (03) :F352-F359

[10]

Dehydration activates an NF-κB-driven, COX2-dependent survival mechanism in renal medullary interstitial cells [J].

Hao, CM ;

Yull, F ;

Blackwell, T ;

Kömhoff, M ;

Davis, LS ;

Breyer, MD .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (08) :973-982

← 1 2 3 4 →