Studies towards the identification of potent, selective and bioavailable thrombin inhibitors

被引：9

作者：

Ambler, J ^{[1
]}

Baker, E ^{[1
]}

Bentley, D ^{[1
]}

Brown, L ^{[1
]}

Butler, K ^{[1
]}

Butler, P ^{[1
]}

Farr, D ^{[1
]}

Dunnet, K ^{[1
]}

Le Grand, D ^{[1
]}

Hayler, J ^{[1
]}

Janus, D ^{[1
]}

Jones, D ^{[1
]}

Menear, K ^{[1
]}

Mercer, M ^{[1
]}

Smith, G ^{[1
]}

Talbot, M ^{[1
]}

Tweed, M ^{[1
]}

机构：

[1] Novartis Horsham Res Ctr, Horsham RH12 4AB, W Sussex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(99)00061-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The application of selection criteria, based on potency and physicochemical parameters, to a candidate library of thrombin inhibitors is described. The utility of the approach is exemplified by the discovery of a potent, selective and bioavailable thrombin inhibitor 62. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：737 / 742

页数：6

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