Dysideaprolines A-F and barbaleucamides A-B, novel polychlorinated compounds from a Dysidea species

被引:31
作者
Harrigan, GG
Goetz, GH
Luesch, H
Yang, ST
Likos, J
机构
[1] Pharmacia Corp, St Louis, MO 63198 USA
[2] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 09期
关键词
D O I
10.1021/np0101999
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Chemical investigation of a marine sponge, Dysidea sp., collected at Bararin Island, Philippines, has afforded the novel metabolites 1-6, proline-derived analogues of dysidenin (7). We have termed compounds 1-6 dysideaprolines A-F, respectively. Also isolated were compounds 8 and 9, structural analogues of barbamide (10), a metabolite originally isolated from the cyanobacterium Lyngbya majuscula. We have termed these novel compounds barbaleucamides A (8) and B (9). It is most probable that the compounds presented here are actually derived from a symbiotic cyanobacterium found in close association with the Dysidea sp. Structure elucidation of the isolated metabolites involved high-field 2D NMR spectroscopy including H-1-H-1 COSY, HSQC, and HMBC.
引用
收藏
页码:1133 / 1138
页数:6
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