A randomized controlled trial of a moderate-fat, low-energy diet compared with a low fat, low-energy diet for weight loss in overweight adults

被引:242
作者
McManus, K
Antinoro, L
Sacks, F
机构
[1] Brigham & Womens Hosp, Dept Nutr, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA USA
[5] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
关键词
diets; weight reduction; unsaturated fat; low fat;
D O I
10.1038/sj.ijo.0801796
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
CONTEXT: Long-term success in weight loss with dietary treatment has been elusive. OBJECTIVE: To evaluate a diet moderate in fat based on the Mediterranean diet compared to a standard low-fat diet for weight loss when both were controlled for energy. DESIGN: A randomized, prospective 18 month trial in a free-living population. PATIENTS: A total of 101 overweight men and women (26.5-46 kg /m(2)). INTERVENTION: (1) Moderate-fat diet (35% of energy); (2) low-fat diet (20% of energy). MAIN OUTCOME MEASUREMENTS: Change in body weight. RESULTS: After 18 months, 31/50 subjects in the moderate-fat group, and 30/51 in the low fat group were available for measurements. In the moderate-fat group, there were mean decreases in body weight of 4.1 kg, body mass index of 1.6 kg/m(2), and waist circumference of 6.9 cm, compared to increases in the low-fat group of 2.9 kg, 1.4 kg/m(2) and 2.6cm, respectively; P less than or equal to 0.001 between the groups. The difference in weight change between the groups was 7.0 kg. (95% Cl 5.3, 8.7). Only 20% (10/51) of those in the low-fat group were actively participating in the weight 105S program after 18 months compared to 54% (27/50) in the moderate-fat group, (P < 0.002). The moderate-fat diet group was continued for an additional year. The mean weight loss after 30 months compared to baseline was 3.5 kg (n = 19, P= 0.03). CONCLUSIONS: A moderate-fat, Mediterranean-style diet, controlled in energy, offers an alternative to a low-fat diet with superior long-term participation and adherence, with consequent improvements in weight loss.
引用
收藏
页码:1503 / 1511
页数:9
相关论文
共 33 条
[1]  
[Anonymous], 1989, SAS STAT US GUID VER
[2]  
Bell EA, 1998, AM J CLIN NUTR, V67, P412
[3]   ASSESSMENT OF HABITUAL PHYSICAL-ACTIVITY BY A 7-DAY RECALL IN A COMMUNITY SURVEY AND CONTROLLED EXPERIMENTS [J].
BLAIR, SN ;
HASKELL, WL ;
HO, P ;
PAFFENBARGER, RS ;
VRANIZAN, KM ;
FARQUHAR, JW ;
WOOD, PD .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 1985, 122 (05) :794-804
[4]   Passive overconsumption - Fat intake and short-term energy balance [J].
Blundell, JE ;
Macdiarmid, JI .
LIPIDS AND SYNDROMES OF INSULIN RESISTANCE: FROM MOLECULAR BIOLOGY TO CLINICAL MEDICINE, 1997, 827 :392-407
[5]   Obesity: a time bomb to be defused [J].
Bray, GA .
LANCET, 1998, 352 (9123) :160-161
[6]  
DAVIS PO, 1988, MED SCI SPORTS EXERC, P20
[7]   FOOD PREFERENCES IN HUMAN OBESITY - CARBOHYDRATES VERSUS FATS [J].
DREWNOWSKI, A ;
KURTH, C ;
HOLDENWILTSE, J ;
SAARI, J .
APPETITE, 1992, 18 (03) :207-221
[8]   REPRODUCIBILITY AND VALIDITY OF FOOD-INTAKE MEASUREMENTS FROM A SEMIQUANTITATIVE FOOD FREQUENCY QUESTIONNAIRE [J].
FESKANICH, D ;
RIMM, EB ;
GIOVANNUCCI, EL ;
COLDITZ, GA ;
STAMPFER, MJ ;
LITIN, LB ;
WILLETT, WC .
JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION, 1993, 93 (07) :790-796
[10]   Fuel partitioning and food intake [J].
Friedman, MI .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1998, 67 (03) :513S-518S