Promiscuous regulator of xenobiotic removal

被引:37
作者
Schuetz, E
Strom, S
机构
[1] St Jude Childrens Res Hosp, Memphis, TN 38105 USA
[2] Univ Pittsburgh, Pittsburgh, PA USA
关键词
D O I
10.1038/87856
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The transcription factor SXR mediates drug, xenobiotic and steroid induction of a major drug-metabolizing enzyme. Drugs such as paclitaxel (Taxol) can bind and activate this transcription factor and therefore regulate their own metabolism and efflux from cells. Manipulation of this pathway might lead to new ways to improve therapeutic efficacy and to minimize toxicity (584-590).
引用
收藏
页码:536 / 537
页数:2
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