Angiogenesis and oxidative stress: Common mechanisms linking psoriasis with atherosclerosis

被引:135
作者
Armstrong, April W. [1 ]
Voyles, Stephanie V. [1 ]
Armstrong, Ehrin J. [2 ]
Fuller, Erin N. [3 ]
Rutledge, John C. [2 ]
机构
[1] Univ Calif Davis, Dept Dermatol, Sacramento, CA 95817 USA
[2] Univ Calif Davis, Div Cardiovasc Med, Sacramento, CA 95817 USA
[3] Univ Hawaii, John A Burns Sch Med, Honolulu, HI 96822 USA
关键词
Psoriasis; Atherosclerosis; Angiogenesis; Oxidative stress; ENDOTHELIAL-GROWTH-FACTOR; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; ACUTE CORONARY SYNDROMES; SMOOTH-MUSCLE-CELLS; SINGLE-NUCLEOTIDE POLYMORPHISMS; MYOCARDIAL-INFARCTION; NAD(P)H OXIDASE; ARTERY-DISEASE; SKIN-DISEASE;
D O I
10.1016/j.jdermsci.2011.04.007
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Shared angiogenic and oxidative mechanisms underlie the pathophysiology of psoriasis and atherosclerosis. During the pathogenesis of both diseases, stimuli such as injury or local hypoxia trigger the release of pro-angiogenic factors including IL-8, HIF-1 alpha, ETS-1, and VEGF. These factors stimulate increased permeability and encourage leukocyte transmigration into areas of inflammation by enhanced expression of cell adhesion molecules. Psoriasis and atherosclerosis also share common enzymatic sources of reactive oxygen species (ROS), and these ROS influence several cellular signaling pathways implicated in the pathogenesis of both diseases. Pharmacologic and genetic therapies that target key factors in these pathways could provide innovative approaches to the management of psoriasis and potentially mitigate the cardiovascular complications suffered by psoriasis patients. (C) 2011 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:1 / 9
页数:9
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