Pathogen recognition: TLRs throw us a curve

被引：39

作者：

Kirk, P ^{[1
]}

Bazan, JF ^{[1
]}

机构：

[1] Genentech Inc, Dept Mol Biol, Dept Prot Engn, San Francisco, CA 94080 USA

来源：

IMMUNITY | 2005年 / 23卷 / 04期

关键词：

D O I：

10.1016/j.immuni.2005.09.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are the archetypal pattern recognition receptors (PRRs) envisioned by Janeway (1989) as innate sensors of pathogen attack and host triggers of an adaptive immune response. Two recent papers (Choe et al., 2005; Bell et al., 2005) reveal the distinctive architecture of a TLR sensor domain and hint at how this structural design facilitates the recognition of a wide array of pathogen molecules.

引用

页码：347 / 350

页数：4

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