Essential role of miRNAs in orchestrating the biology of the tumor microenvironment

被引：56

作者：

Frediani, Jamie N. ^{[1
,2
]}

Fabbri, Muller ^{[1
,2
,3
,4
,5
]}

机构：

[1] Childrens Hosp Los Angeles, Childrens Ctr Canc & Blood Dis, Los Angeles, CA 90027 USA

[2] Childrens Hosp Los Angeles, Saban Res Inst, Los Angeles, CA 90027 USA

[3] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Pediat, Los Angeles, CA 90033 USA

[4] Univ So Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Dept Microbiol & Immunol, Los Angeles, CA 90033 USA

[5] 34650 Sunset Blvd MS 57, Los Angeles, CA 90027 USA

来源：

MOLECULAR CANCER | 2016年 / 15卷

关键词：

Exosomes; microRNAs; Tumor microenvironment; Cancer; CANCER-ASSOCIATED FIBROBLASTS; MESENCHYMAL STEM-CELLS; PROSTATE-CANCER; DOWN-REGULATION; HEPATOCELLULAR-CARCINOMA; CLINICAL-SIGNIFICANCE; SERUM MIR-21; LUNG-CANCER; MICRORNA; ANGIOGENESIS;

D O I：

10.1186/s12943-016-0525-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression levels within the different cells of the TME and by being shuttled among different cell populations within exosomes and other extracellular vesicles. This review focuses on the state-of-the-art knowledge of the role of miRNAs in the complexity of the TME and highlights limitations and challenges in the field. A better understanding of the mechanisms of action of these fascinating micro molecules will lead to the development of new therapeutic weapons and most importantly, to an improvement in the clinical outcome of cancer patients.

引用

页数：11

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