学术探索
学术期刊
新闻热点
数据分析
智能评审

Renin inhibition: What are the therapeutic opportunities?

被引：149
作者：
Fisher, NDL
Hollenberg, NK
机构：
[1] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA
来源：
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 2005年 / 16卷 / 03期
关键词：
D O I：
10.1681/ASN.2004100874
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Blockade of the renin-angiotensin system with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers has become a crucial element in cardiovascular and renal medicine. This review evaluates the potential of renin inhibition as an adjunct to therapies that depend on renin system interruption.
引用
收藏
页码：592 / 599
页数：8
相关论文
共 51 条
  • [1] Dual blockade with candesartan cilexetil and lisinopril in hypertensive patients with diabetes mellitus:: rationale and design
    Andersen, NH
    Knudsen, ST
    Poulsen, PL
    Poulsen, SH
    Helleberg, K
    Eiskjær, H
    Hansen, KW
    Bek, T
    Mogensen, CE
    [J]. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 2003, 4 (02) : 96 - 99
  • [2] BEZENCON O, 2004, 228 NAT M PHIL PA AU
  • [3] CONTROL ANALYSIS APPLIED TO SINGLE ENZYMES - CAN AN ISOLATED ENZYME HAVE A UNIQUE RATE-LIMITING STEP
    BROWN, GC
    COOPER, CE
    [J]. BIOCHEMICAL JOURNAL, 1993, 294 : 87 - 94
  • [4] SPECIFIC-INHIBITION OF RENIN BY AN ANGIOTENSINOGEN ANALOG - STUDIES IN SODIUM DEPLETION AND RENIN-DEPENDENT HYPERTENSION
    BURTON, J
    CODY, RJ
    HERD, JA
    HABER, E
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (09): : 5476 - 5479
  • [5] RENAL AND ENDOCRINE RESPONSES TO A RENIN INHIBITOR, ENALKIREN, IN NORMAL HUMANS
    CORDERO, P
    FISHER, ND
    MOORE, TJ
    GLEASON, R
    WILLIAMS, GH
    HOLLENBERG, NK
    [J]. HYPERTENSION, 1991, 17 (04) : 510 - 516
  • [6] RENIN, PRORENIN, AND IMMUNOREACTIVE RENIN IN VITREOUS FLUID FROM EYES WITH AND WITHOUT DIABETIC-RETINOPATHY
    DANSER, AHJ
    VANDENDORPEL, MA
    DEINUM, J
    DERKX, FHM
    FRANKEN, AAM
    PEPERKAMP, E
    DEJONG, PTVM
    SCHALEKAMP, MADH
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1989, 68 (01) : 160 - 167
  • [7] IDENTIFICATION AND QUANTIFICATION OF RENIN AND PRORENIN IN THE BOVINE EYE
    DEINUM, J
    DERKX, FHM
    DANSER, AHJ
    SCHALEKAMP, MADH
    [J]. ENDOCRINOLOGY, 1990, 126 (03) : 1673 - 1682
  • [8] DERKX FHM, 1987, THESIS ERASMUS U ROT
  • [9] ANTIBODIES AS SPECIFIC RENIN INHIBITORS - STUDIES WITH POLYCLONAL AND MONOCLONAL-ANTIBODIES AND FAB FRAGMENTS
    DZAU, VJ
    DEVINE, D
    MUDGETTHUNTER, M
    KOPELMAN, RI
    BARGER, AC
    HABER, E
    [J]. CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1983, 5 (7-8) : 1207 - 1220
  • [10] EFFECTS OF BLOCKING THE ANGIOTENSIN-II RECEPTOR, CONVERTING-ENZYME, AND RENIN-ACTIVITY ON THE RENAL HEMODYNAMICS OF NORMOTENSIVE GUINEA-PIGS
    ELAMRANI, AIK
    MENARD, J
    GONZALES, MF
    MICHEL, JB
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1993, 22 (02) : 231 - 239
123456