An entry to a chiral dihydropyrazole scaffold: Enantioselective [3+2] cycloaddition of nitrile imines

被引：124

作者：

Sibi, MP ^{[1
]}

Stanley, LM ^{[1
]}

Jasperse, CP ^{[1
]}

机构：

[1] N Dakota State Univ, Dept Chem, Fargo, ND 58105 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 23期

关键词：

D O I：

10.1021/ja051650b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have developed a versatile strategy to access dihydropyrazoles in highly enantioenriched form. Dipolar cycloaddition of electron-deficient acceptors and in situ-generated nitrile imines proceeds with high regio- and enantioselectivity using 10 mol % chiral Lewis acid catalyst. A variety of dihydropyrazoles that incorporate functionality for further manipulation have been prepared. Copyright © 2005 American Chemical Society.

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页码：8276 / 8277

页数：2

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