Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis

被引：37

作者：

Dean, J. P. ^{[1
]}

Nelson, P. S. ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Human Biol & Clin Res, Seattle, WA 98109 USA

来源：

BRITISH JOURNAL OF CANCER | 2008年 / 98卷 / 02期

关键词：

prostate; gene expression; senescence; paracrine; carcinogenesis;

D O I：

10.1038/sj.bjc.6604087

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Experimental evidence suggests that ageing-associated alterations in the tissue microenvironment act to promote prostate carcinogenesis. In this review, we survey the cellular state of senescence, review its causes, and describe associations with ageing and cancer. We further discuss senescent stromal gene expression changes, which may mediate these effects, and that may serve as therapeutic targets.

引用

页码：245 / 249

页数：5

共 31 条

[1] The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
Bavik, C
Coleman, I
Dean, JP
Knudsen, B
Plymate, S
Nelson, PS
[J]. CANCER RESEARCH, 2006, 66 (02) : 794 - 802
[2] CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitro
Begley, L
Monteleon, C
Shah, RB
MacDonald, JW
Macoska, JA
[J]. AGING CELL, 2005, 4 (06) : 291 - 298
[3] TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
Bhowmick, NA
Chytil, A
Plieth, D
Gorska, AE
Dumont, N
Shappell, S
Washington, MK
Neilson, EG
Moses, HL
[J]. SCIENCE, 2004, 303 (5659) : 848 - 851
[4] Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, ZB
Trotman, LC
Shaffer, D
Lin, HK
Dotan, ZA
Niki, M
Koutcher, JA
Scher, HI
Ludwig, T
Gerald, W
Cordon-Cardo, C
Pandolfi, PP
[J]. NATURE, 2005, 436 (7051) : 725 - 730
[5] Tumour biology -: Senescence in premalignant tumours
Collado, M
Gil, J
Efeyan, A
Guerra, C
Schuhmacher, AJ
Barradas, M
Benguría, A
Zaballos, A
Flores, JM
Barbacid, M
Beach, D
Serrano, M
[J]. NATURE, 2005, 436 (7051) : 642 - 642
[6] CULIG Z, 1994, CANCER RES, V54, P5474
[7] Role of the stromal microenvironment in carcinogenesis of the prostate
Cunha, GR
Hayward, SW
Wang, YZ
Ricke, WA
[J]. INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (01) : 1 - 10
[8] A BIOMARKER THAT IDENTIFIES SENESCENT HUMAN-CELLS IN CULTURE AND IN AGING SKIN IN-VIVO
DIMRI, GP
LEE, XH
BASILE, G
ACOSTA, M
SCOTT, C
ROSKELLEY, C
MEDRANO, EE
LINSKENS, M
RUBELJ, I
PEREIRASMITH, O
PEACOCKE, M
CAMPISI, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) : 9363 - 9367
[9] Prostate tumor CXC-chemokine profile correlates with cell adhesion to endothelium and extracellular matrix
Engl, T
Relja, B
Blumenberg, C
Müller, I
Ringel, EM
Beecken, WD
Jonas, D
Blaheta, RA
[J]. LIFE SCIENCES, 2006, 78 (16) : 1784 - 1793
[10] Cellular senescence in aging primates
Herbig, U
Ferreira, M
Condel, L
Carey, D
Sedivy, JM
[J]. SCIENCE, 2006, 311 (5765) : 1257 - 1257

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