Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion

被引：230

作者：

Hamann, GF

Okada, Y

delZoppo, GJ

机构：

[1] Scripps Res Inst, DEPT MOL & EXPT MED, LA JOLLA, CA 92037 USA

[2] UNIV SAARLAND, DEPT NEUROL, D-6650 HOMBURG, GERMANY

[3] NATL KYUSHU MED CTR HOSP, CEREBROVASC DIS CLIN, FUKUOKA, JAPAN

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 1996年 / 16卷 / 06期

关键词：

basal lamina; cerebral ischemia; hemorrhage; laminin;

D O I：

10.1097/00004647-199611000-00036

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hemorrhagic transformation after cerebral ischemia is a well known clinical concern. The frequency of intact basal lamina (BL), identified by laminin antigen, in hemorrhagic and nonhemorrhagic zones after middle cerebral artery occlusion (MCA:O) and 3-h MCA:O with reperfusion in adolescent male baboons was assessed. Parenchymal hemoglobin was not detected prior to 24-h reperfusion. A significant decrease in the density of laminin (BL) in hemorrhagic zones (6.2 +/- 2.4) compared with nonhemorrhagic ischemic zones (10.5 +/- 2.4) (p < 0.05) and nonischemic basal ganglia (17.0 +/- 2.7) (p < 0.01) was observed. Time-dependent changes in BL integrity appear linked to the extravasation of blood components.

引用

页码：1373 / 1378

页数：6

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