A blue fluorescent anti body-cofactor sensor for mercury

被引：138

作者：

Matsushita, M

Meijler, MM

Wirsching, P

Lerner, RA

Janda, KD

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol051919w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A chemically programmed antibody sensor, consisting of a stilbenyl boronic acid cofactor and monoclonal antibody EP2-19G2, provides a new method of mercury detection. The fluorescent antibody sensor generates an intense powder blue fluorescence when bound to the stilbenyl boronic acid cofactor; however, it is quenched in the presence of Hg2+ ions. The EP2-19G2-cofactor biosensor provides micromolar sensitivity and selectivity toward Hg2+ ions over a wide range of metal ions in aqueous solution.

引用

收藏

页码：4943 / 4946

页数：4

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