Patented small molecule inhibitors in the ubiquitin proteasome system

被引：60

作者：

Guedat, Philippe ^{[1
]}

Colland, Frederic ^{[1
]}

机构：

[1] Hybrigenics SA, F-75014 Paris, France

来源：

BMC BIOCHEMISTRY | 2007年 / 8卷

关键词：

D O I：

10.1186/1471-2091-8-S1-S14

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Deregulation of the ubiquitin proteasome system (UPS) has been implicated in the pathogenesis of many human diseases, including cancer and neurodegenerative disorders. The recent approval of the proteasome inhibitor Velcade (R) (bortezomib) for the treatment of multiple myeloma and mantle cell lymphoma establishes this system as a valid target for cancer treatment. We review here new patented proteasome inhibitors and patented small molecule inhibitors targeting more specific UPS components, such as E3 ubiquitin ligases and deubiquitylating enzymes.

引用

页数：12

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