Elevated interleukin-27 enhances the polarization of Th1/Tc1 cells and the production of proinflammatory cytokines in primary immune thrombocytopenia

被引：35

作者：

Li, Hui Yuan ^{[1
,2
,3
]}

Zhang, Dong Lei ^{[1
,2
,3
]}

Ge, Jing ^{[1
,2
,3
]}

Zhou, Hu ^{[1
,2
,3
]}

Qi, Ai Ping ^{[1
,2
,3
]}

Ma, Li ^{[1
,2
,3
]}

Xue, Feng ^{[1
,2
,3
]}

Zhou, Ze Ping ^{[1
,2
,3
,4
]}

Yang, Ren Chi ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China

[2] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin 300020, Peoples R China

[3] Peking Union Med Coll, Tianjin 300020, Peoples R China

[4] Kunming Med Univ, Affiliated Hosp 2, Dept Hematol, Kunming 650101, Peoples R China

来源：

HUMAN IMMUNOLOGY | 2012年 / 73卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Primary immune thrombocytopenia; Interleukin-27; Proinflammatory cytokines; Th1; Tc1; REGULATORY T-CELLS; DENDRITIC CELLS; ADULT PATIENTS; PURPURA ITP; IL-27; TH17; EXPRESSION; PROFILE; TYPE-1; PATHOPHYSIOLOGY;

D O I：

10.1016/j.humimm.2011.12.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Primary immune thrombocytopenia (ITP) is an acquired, organ-specific, autoimmune disease with many immune dysfunctions. Interleukin-27 (IL-27) can regulate T cell differentiation. However, it is unclear whether IL-27 correlates with the dysfunctions of T cell differentiation in ITP patients. Thus, to determine the roles of IL-27 in ITP, we studied the expression of IL-27/IL-27 receptor in ITP patients. The results indicated that the levels of IL-27 in the plasma of untreated active ITP patients were higher than in normal controls. We next evaluated the contribution of IL-27 to T cell differentiation. Our results indicated that IL-27 increased T-bet expression, inhibited GATA-3 and ROR-gamma t expression, and promoted the secretion of tumor necrosis factor-alpha, interferon-gamma, and granzyme B of peripheral blood mononuclear cells from ITP patients. Also, we confirmed that IL-27 induced the differentiation of T helper (Th)-1 and Tc1 cells. In conclusion, IL-27 might play an important role in the pathogenesis of ITP by inducing the polarization of Th1/Tc1 cells and the production of proinflammatory cytokines. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：240 / 247

页数：8

共 41 条

[1]

Dendritic cells of immune thrombocytopenic purpura (ITP) show increased capacity to present apoptotic platelets to T lymphocytes [J].