Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach

被引：283

作者：

Bhattacharya, Manojit ^{[1
,2
]}

Sharma, Ashish R. ^{[1
]}

Patra, Prasanta ^{[2
]}

Ghosh, Pratik ^{[2
]}

Sharma, Garima ^{[3
]}

Patra, Bidhan C. ^{[2
]}

Lee, Sang-Soo ^{[1
]}

Chakraborty, Chiranjib ^{[1
,4
]}

机构：

[1] Hallym Univ, Chuncheon Sacred Heart Hosp, Inst Skeletal Aging & Orthoped Surg, Chuncheon Si 24252, Gangwon Do, South Korea

[2] Vidyasagar Univ, Dept Zool, Midnapore, W Bengal, India

[3] Kangwon Natl Univ, Coll Pharm, Neuropsychopharmacol & Toxicol Program, Chunchon, South Korea

[4] Adamas Univ, Sch Life Sci & Biotechnol, Dept Biotechnol, Barasat Barrackpore Rd, Kolkata 700126, W Bengal, India

来源：

JOURNAL OF MEDICAL VIROLOGY | 2020年 / 92卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

epitopes; immunoinformatics; SARS-COV-2; vaccine; GLOBAL HEALTH; PROTEIN; PREDICTION; RECOGNITION; OUTBREAK;

D O I：

10.1002/jmv.25736

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.

引用

页码：618 / 631

页数：14

共 26 条

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