Contact-dependent inhibition of growth in Escherichia coli

被引：323

作者：

Aoki, SK ^{[1
]}

Pamma, R ^{[1
]}

Hernday, AD ^{[1
]}

Bickham, JE ^{[1
]}

Braaten, BA ^{[1
]}

Low, DA ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Santa Barbara, CA 93106 USA

来源：

SCIENCE | 2005年 / 309卷 / 5738期

关键词：

D O I：

10.1126/science.1115109

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bacteria have developed mechanisms to communicate and compete with each other for Limited environmental resources. We found that certain Escherichia coli, including uropathogenic strains, contained. a bacterial growth-inhibition system that uses direct cell-to-cell contact. Inhibition was conditional, dependent upon the growth state of the inhibitory cell and the pili expression state of the target cell. Both a large cell-surface protein designated Contact-dependent inhibitor A (CdiA) and two-partner secretion family member CdiB were required for growth inhibition. The CdiAB system may function to regulate the growth of specific cells within a differentiated bacterial population.

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页码：1245 / 1248

页数：4

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