Peak capacity in unidimensional chromatography

被引：131

作者：

Neue, Uwe Dieter ^{[1
]}

机构：

[1] Waters Corp, Milford, MA 01757 USA

来源：

JOURNAL OF CHROMATOGRAPHY A | 2008年 / 1184卷 / 1-2期

关键词：

peak capacity; resolution; gradient chromatography; peak compression; peak overlap; peptides; Oligonucleotides; ion-exchange chromatography; size-exclusion chromatography;

D O I：

10.1016/j.chroma.2007.11.113

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The currently existing knowledge about peak capacity in unidimensional separations is reviewed. The majority of the paper is dedicated to reversed-phase gradient chromatography, covering specific techniques as well as the subject of peak compression. Other sections deal with peak capacity in isocratic chromatography, size-exclusion chromatography and ion-exchange chromatography. An important topic is the limitation of the separation power and the meaning of the concept of peak capacity for real applications. (c) 2007 Elsevier B.V. All rights reserved.

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页码：107 / 130

页数：24

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