P57 (KIP2) polymorphisms and breast cancer risk

被引：12

作者：

Li, Y

Millikan, RC

Newman, B

Conway, K

Tse, CKJ

Liu, ET

机构：

[1] Univ N Carolina, Dept Epidemiol, Sch Publ Hlth, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] NCI, Div Clin Sci, Bethesda, MD 20892 USA

来源：

HUMAN GENETICS | 1999年 / 104卷 / 01期

关键词：

D O I：

10.1007/s004390050914

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A previous report in this journal has suggested that germline deletions in the proline-alanine-rich (PAPA-repeat) region of P57 (KIP2) are associated with increased risk of a variety of cancers, including breast cancer. We have analyzed the association of P57 PAPA-repeat deletion polymorphisms and breast cancer risk as part of a population-based case-control study of breast cancer. We have not observed an association between the presence of one or two copies of deletion polymorphisms in P57 and breast cancer risk (adjusted odds ratio: 1.1, 95% confidence interval: 0.6-2.0), Further investigation is necessary to determine the functional significance of P57 deletion polymorphisms and their potential relationship with disease.

引用

页码：83 / 88

页数：6

共 25 条

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