Local adipose tissue renin-angiotensin system

被引：183

作者：

Cassis, Lisa A. ^{[1
]}

Police, Sara B. ^{[1
]}

Yiannikouris, Frederique ^{[1
]}

Thatcher, Sean E. ^{[1
]}

机构：

[1] Univ Kentucky, Grad Ctr Nutr Sci, Lexington, KY 40536 USA

来源：

CURRENT HYPERTENSION REPORTS | 2008年 / 10卷 / 02期

关键词：

D O I：

10.1007/s11906-008-0019-9

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

A local renin-angiotensin system (RAS) has been proposed in adipocytes. Adipocytes are a suggested source of components of the RAS, with regulation of their production related to obesity-hypertension. Both angiotensin type 1 and 2 receptors have been localized to adipocytes. Angiotensin II has been demonstrated to regulate adipocyte growth and differentiation, lipid metabolism, and expression and release of adipokines and RAS components, and to promote oxidative stress. Differences in regional expression of RAS components in visceral versus subcutaneous adipose tissue have been suggested as a link between abdominal obesity and cardiovascular disease. Finally, several studies support anti hypertensive efficacy of RAS blockade in patients with type 2 diabetes and obesity. Future studies should address the role of adipocyte-specific deficiency of RAS components to definitively determine the relevance of the adipose RAS to normal physiology and to the development of hypertension.

引用

页码：93 / 98

页数：6

共 43 条

[1] HETEROGENEITY IN ADIPOSE-TISSUE METABOLISM - CAUSES, IMPLICATIONS AND MANAGEMENT OF REGIONAL ADIPOSITY [J].

ABATE, N ;

GARG, A .

PROGRESS IN LIPID RESEARCH, 1995, 34 (01) :53-70

[2] Renin receptor expression in human adipose tissue [J].

Achard, Vincent ;

Boullu-Ciocca, Sandrine ;

Desbriere, Raoul ;

Nguyen, Genevieve ;

Grino, Michel .

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2007, 292 (01) :R274-R282

[3] Cross talk between adipocytes and their precursors: Relationships with adipose tissue development and blood pressure [J].

Ailhaud, G .

THE METABOLIC SYNDROME X: CONVERGENCE OF INSULIN RESISTANCE, GLUCOSE INTOLERANCE, HYPERTENSION, OBESITY, AND DYSLIPIDEMIAS-SEARCHING FOR THE UNDERLYING DEFECTS, 1999, 892 :127-133

[4] Adiposopathy: Treating pathogenic adipose tissue to reduce cardiovascular disease risk [J].

Bays H. ;

Rodbard H.W. ;

Schorr A.B. ;

González-Campoy J.M. .

Current Treatment Options in Cardiovascular Medicine, 2007, 9 (4) :259-271

[5] Addressing the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome in the Southeastern United States, Part II: Treatment recommendations for management of the global cardiovascular risk of hypertension, dyslipidemia, diabetes mellitus, and the metabolic syndrome [J].

Bestermann, W ;

Houston, MC ;

Basile, J ;

Egan, B ;

Ferrario, CM ;

Lackland, D ;

Hawkins, RG ;

Reed, J ;

Rogers, P ;

Wise, D ;

Moore, MA .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2005, 329 (06) :292-305

[6] Larger anti-adipogenic effect of angiotensin II on omental preadipose cells of obese humans [J].

Bruecher, Rodrigo ;

Cifuentes, Mariana ;

Jose Acuna, Maria ;

Albala, Cecilia ;

Rojas, Cecilia V. .

OBESITY, 2007, 15 (07) :1643-1646

[7]

Bujak-Gizycka B, 2007, J PHYSIOL PHARMACOL, V58, P529

[8] CELLULAR-LOCALIZATION OF ANGIOTENSINOGEN GENE-EXPRESSION IN BROWN ADIPOSE-TISSUE AND MESENTERY - QUANTIFICATION OF MESSENGER-RIBONUCLEIC-ACID ABUNDANCE USING HYBRIDIZATION INSITU [J].

CAMPBELL, DJ ;

HABENER, JF .

ENDOCRINOLOGY, 1987, 121 (05) :1616-1626

[9]

CASSIS L, 2006, COUNC HIGH BLOOD PRE

[10] Fat cell metabolism: Insulin, fatty acids, and renin [J].

Cassis L.A. .

Current Hypertension Reports, 2000, 2 (2) :132-138

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