Exact and Approximate Area-Proportional Circular Venn and Euler Diagrams

被引:100
作者
Wilkinson, Leland [1 ]
机构
[1] Systat Software Inc, Chicago, IL 60606 USA
基金
美国国家科学基金会;
关键词
Visualization; bioinformatics; statistical graphics; MONTE-CARLO; GENE-EXPRESSION; RANDOM RANKINGS; WEB APPLICATION;
D O I
10.1109/TVCG.2011.56
中图分类号
TP31 [计算机软件];
学科分类号
081205 [计算机软件];
摘要
Scientists conducting microarray and other experiments use circular Venn and Euler diagrams to analyze and illustrate their results. As one solution to this problem, this paper introduces a statistical model for fitting area-proportional Venn and Euler diagrams to observed data. The statistical model outlined in this paper includes a statistical loss function and a minimization procedure that enables formal estimation of the Venn/Euler area-proportional model for the first time. A significance test of the null hypothesis is computed for the solution. Residuals from the model are available for inspection. As a result, this algorithm can be used for both exploration and inference on real data sets. A Java program implementing this algorithm is available under the Mozilla Public License. An R function venneuler( ) is available as a package in CRAN and a plugin is available in Cytoscape.
引用
收藏
页码:321 / 331
页数:11
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