Multiplexing and multivariate analysis in neurodegeneration

被引：12

作者：

Andreasson, Ulf ^{[1
]}

Portelius, Erik ^{[1
]}

Pannee, Josef ^{[1
]}

Zetterberg, Henrik ^{[1
]}

Blennow, Kaj ^{[1
]}

机构：

[1] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad, SE-43180 Molndal, Sweden

来源：

METHODS | 2012年 / 56卷 / 04期

关键词：

Multiplex; Mass spectrometry; Multivariate analysis; Neurodegeneration; HUMAN CEREBROSPINAL-FLUID; ALZHEIMERS ASSOCIATION WORKGROUPS; TANDEM MASS-SPECTROMETRY; AMYLOID-BETA PEPTIDES; ELECTROSPRAY-IONIZATION; MATRIX METALLOPROTEINASES; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; DISEASE; PROTEOMICS;

D O I：

10.1016/j.ymeth.2012.02.004

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Limited sample volume is often an obstacle in clinical research and one way to circumvent this is to use multiplex techniques where several different analytes are simultaneously measured. There is a multitude of different platforms that can be used for multiplexing and their uniqueness and similarities will be described. Multivariate analysis is a powerful tool for extracting information from multiplex data. An introduction to one such algorithm is presented followed by examples from the literature, in the field of neurodegeneration, where multiplex and multivariate methods have been used. (c) 2012 Elsevier Inc. All rights reserved.

引用

页码：464 / 470

页数：7

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