Vitamin D and type 1 diabetes mellitus: state of the art

被引：154

作者：

Mathieu, C ^{[1
]}

Badenhoop, K

机构：

[1] Katholieke Univ Leuven, Lab Expt Med & Endocrinol, B-3000 Louvain, Belgium

[2] Univ Hosp Frankfurt, Dept Med 1, Div Endocrinol Diabet & Metab, D-60590 Frankfurt, Germany

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2005年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.tem.2005.06.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence suggests a role for vitamin D in pathogenesis and prevention of diabetes mellitus. Active vitamin D, 1 alpha,25(OH)(2)D-3, prevents type 1 diabetes in animal models, modifies T-cell differentiation, modulates dendritic cell action and induces cytokine secretion, shifting the balance to regulatory T cells. High-dose vitamin D supplementation early in life protects against type 1 diabetes. 1 alpha,25(OH)(2)D-3 activity is mediated through its receptor, and targets include transcriptional regulators; therefore, 1 alpha,25(OH)(2)D-3 influences gene transcription. 1 alpha,25(OH)(2)D-3 also affects pancreatic beta-cell function. Genomic variations of vitamin D metabolism and target cell action predispose to type 1 diabetes. Vitamin D deficiency in pregnancy probably increases the incidence of autoimmune diseases, such as type 1 diabetes, in genetically predisposed individuals. Pharmacotherapy with 1 alpha,25(OH)(2)D-3 analogues might help prevent and treat diabetes.

引用

页码：261 / 266

页数：6

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