Astrocytes induce manganese superoxide dismutase in brain capillary endothelial cells

被引：19

作者：

Schroeter, ML

Müller, S

Lindenau, J

Wiesner, B

Hanisch, UK

Wolf, G

Blasig, IE

机构：

[1] Max Planck Inst Cognit Neurosci, D-04103 Leipzig, Germany

[2] Otto Von Guericke Univ, Inst Med Neurobiol, D-39120 Magdeburg, Germany

[3] Max Delbruck Ctr Mol Med, Res Inst Mol Pharmacol, D-13125 Berlin, Germany

来源：

NEUROREPORT | 2001年 / 12卷 / 11期

关键词：

astrocytes; blood-brain barrier; brain capillary endothelial cells; cytokines; free radicals; manganese superoxide dismutase; reactive oxygen species;

D O I：

10.1097/00001756-200108080-00045

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Astrocytes induce blood-brain barrier (BBB) proper-ties in brain endothelial cells (EC). O-2, generated in blood and EC, opens the BBB. Hence, high activity of superoxide dismutase (SOD) is a prerequisite for normal BBB function. Therefore, the influence of rat astrocytes on the expression of manganese (Mn)SOD in rat EC was investigated in two coculture models of the BBB, allowing either exchange of soluble factors or additionally cellular contacts, Activity, protein content and mRNA expression of endothelial MnSOD were significantly increased in both coculture models in comparison to monoculture by soluble astrocytic factors, such as cytokines. High activity of endothelial MnSOD may be considered as a further essential property of the BBB, which is induced and maintained by astrocytes. NeuroReport 12:2513-2517 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：2513 / 2517

页数：5

共 23 条

[1]

ASAYAMA K, 1985, J BIOL CHEM, V260, P2212

[2]

Betz A. Lorris, 1993, P303

[3] MANGANESE SUPEROXIDE-DISMUTASE - A HEPATIC ACUTE PHASE PROTEIN REGULATED BY INTERLEUKIN-6 AND GLUCOCORTICOIDS [J].