A prospective evaluation of the safety and efficacy of TAXUS Element paclitaxel-eluting coronary stent implantation for the treatment of de novo coronary artery lesions in small vessels: the PERSEUS Small Vessel trial

被引：23

作者：

Cannon, Louis A. ^{[2
]}

Kereiakes, Dean J. ^{[1
]}

Mann, Tift ^{[3
]}

Popma, Jeffrey J. ^{[4
]}

Mooney, Michael R. ^{[5
]}

Mishkel, Gregory J. ^{[6
]}

Lee, Tommy C. ^{[7
]}

Wilson, B. Hadley ^{[8
]}

Stuckey, Thomas D. ^{[9
]}

Orlow, Steven ^{[10
]}

McGarry, Thomas ^{[11
]}

Ring, Michael E. ^{[12
]}

Kellett, Mirle A. ^{[13
]}

Underwood, Paul ^{[14
]}

Dawkins, Keith D. ^{[14
]}

机构：

[1] Christ Hosp, Heart & Vasc Ctr, Lindner Ctr Res & Educ, Cincinnati, OH 45219 USA

[2] No Michigan Reg Hosp, Cardiac & Vasc Res Ctr No Michigan, Petoskey, MI USA

[3] Wake Med Ctr, Raleigh, NC USA

[4] Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA

[5] Minneapolis Heart Inst Fdn, Minneapolis, MN USA

[6] St Johns Hosp, Springfield, IL USA

[7] Bakersfield Mem Hosp, Bakersfield, CA USA

[8] Carolinas Med Ctr, Charlotte, NC 28203 USA

[9] LeBauer Cardiovasc Res Fdn, Greensboro, NC USA

[10] Lutheran Hosp Indiana, Ft Wayne, IN USA

[11] Oklahoma Fdn Cardiovasc Res, Oklahoma City, OK USA

[12] Providence Sacred Heart Med Ctr, Spokane, WA USA

[13] Maine Med Ctr, Portland, ME 04102 USA

[14] Boston Sci Corp, Natick, MA USA

来源：

EUROINTERVENTION | 2011年 / 6卷 / 08期

关键词：

Paclitaxel; drug-eluting stents; coronary restenosis; platinum chromium; small vessel; thin-strut; LIBERTE STENT; PROGRAM; DISEASE; SYSTEM;

D O I：

10.4244/EIJV6I8A161

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: Small reference vessel diameter predicts adverse outcomes following coronary stenting. TAXUS Express and TAXUS Liberte paclitaxel-eluting stents (PES) reduce restenosis compared to bare metal stents (BMS) in small diameter vessels. TAXUS Element is a novel thin-strut, platinum chromium stent designed to enhance visibility, conformability, and drug delivery in small diameter vessels. Methods and results: The PERSEUS Small Vessel (SV) prospective, single-arm, superiority trial evaluates the TAXUS Element PES in 224 subjects with target lesion length <= 20 mm and vessel diameter >= 2.25 to <2.75 mm, compared to 125 lesion-matched historical Express BMS control subjects from the TAXUS V trial. The primary endpoint was nine-month in-stent late loss. The secondary endpoint was 12-month target lesion failure (TLF) compared to a pre-specified performance goal (PG). Outcomes were analysed with and without propensity-score adjustment. TAXUS Element was superior to the Express BMS for late loss (0.38 +/- 0.51 versus 0.80 +/- 0.53 mm respectively; P<0.001), and TLF (7.3%) was significantly less than the 19.5% PG (P<0.001). No differences in mortality, myocardial infarction, or stent thrombosis were observed through 12 months. Results were similar after adjustment. Conclusions: PERSEUS SV supports the efficacy and safety of the platinum chromium, thin-strut TAXUS Element stent in small coronary vessels.

引用

页码：920 / 927

页数：8

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