Signal transduction inhibition: Results from phase I clinical trials in chronic myeloid leukemia

被引：30

作者：

Druker, B ^{[1
]}

机构：

[1] Oregon Hlth Sci Univ, Dept Med, Div Hematol & Med Oncol, Portland, OR 97201 USA

来源：

SEMINARS IN HEMATOLOGY | 2001年 / 38卷 / 03期

关键词：

D O I：

10.1053/shem.2001.27079

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：9 / 14

页数：6

共 15 条

[1]

Buchdunger E, 1996, CANCER RES, V56, P100

[2] CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins [J].

Carroll, M ;

OhnoJones, S ;

Tamura, S ;

Buchdunger, E ;

Zimmermann, J ;

Lydon, NB ;

Gilliland, DG ;

Druker, BJ .

BLOOD, 1997, 90 (12) :4947-4952

[3] INDUCTION OF CHRONIC MYELOGENOUS LEUKEMIA IN MICE BY THE P210BCR/ABL GENE OF THE PHILADELPHIA-CHROMOSOME [J].

DALEY, GQ ;

VANETTEN, RA ;

BALTIMORE, D .

SCIENCE, 1990, 247 (4944) :824-830

[4] The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells [J].

Deininger, MWN ;

Goldman, JM ;

Lydon, N ;

Melo, JV .

BLOOD, 1997, 90 (09) :3691-3698

[5] Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the philadelphia chromosome. [J].

Druker, BJ ;

Sawyers, CL ;

Kantarjian, H ;

Resta, DJ ;

Reese, SF ;

Ford, JM ;

Capdeville, R ;

Talpaz, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1038-1042

[6] Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells [J].

Druker, BJ ;

Tamura, S ;

Buchdunger, E ;

Ohno, S ;

Segal, GM ;

Fanning, S ;

Zimmermann, J ;

Lydon, NB .

NATURE MEDICINE, 1996, 2 (05) :561-566

[7] Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. [J].

Druker, BJ ;

Talpaz, M ;

Resta, DJ ;

Peng, B ;

Buchdunger, E ;

Ford, JM ;

Lydon, NB ;

Kantarjian, H ;

Capdeville, R ;

Ohno-Jones, S ;

Sawyers, CL .

NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (14) :1031-1037

[8]

Faderl S, 1999, ONCOLOGY-NY, V13, P169

[9] Inhibition of the ABL kinase activity blocks the proliferation of BCR/ABL(+) leukemic cells and induces apoptosis [J].

GambacortiPasserini, C ;

leCoutre, P ;

Mologni, L ;

Fanelli, M ;

Bertazzoli, C ;

Marchesi, E ;

DiNicola, M ;

Biondi, A ;

Corneo, GM ;

Belotti, D ;

Pogliani, E ;

Lydon, NB .

BLOOD CELLS MOLECULES AND DISEASES, 1997, 23 (19) :380-394

[10] ACUTE-LEUKEMIA IN BCR/ABL TRANSGENIC MICE [J].

HEISTERKAMP, N ;

JENSTER, G ;

TENHOEVE, J ;

ZOVICH, D ;

PATTENGALE, PK ;

GROFFEN, J .

NATURE, 1990, 344 (6263) :251-253

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