The human dopamine transporter gene: gene organization, transcriptional regulation, and potential involvement in neuropsychiatric disorders

被引:114
作者
Bannon, MJ [1 ]
Michelhaugh, SK [1 ]
Wang, J [1 ]
Sacchetti, P [1 ]
机构
[1] Wayne State Univ, Sch Med, Dept Psychiat & Behav Neurosci, Detroit, MI 48201 USA
关键词
expression; transcriptional regulation; gene polymorphisms; neuron-restrictive silencer; nurr1; variable number tandem repeat;
D O I
10.1016/S0924-977X(01)00122-5
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The dopamine transporter is a plasma membrane protein that controls the spatial and temporal domains of dopamine neurotransmission through the accumulation of extracellular dopamine. The dopamine transporter may play a role in numerous dopamine-linked neuropsychiatric disorders. We review the cloning and organization of the human dopamine transporter gene, polymorphisms in its coding and noncoding sequence, and emerging data on its transcriptional regulation. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:449 / 455
页数:7
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