Regulation of interferon-γ production by IL-12 and IL-18

被引:466
作者
Okamura, H
Kashiwamura, S
Tsutsui, H
Yoshimoto, T
Nakanishi, K
机构
[1] Hyogo Coll Med, Inst Adv Med Sci, Host Def Lab, Nishinomiya, Hyogo 6688501, Japan
[2] Hyogo Coll Med, Dept Immunol, Nishinomiya, Hyogo 6688501, Japan
关键词
D O I
10.1016/S0952-7915(98)80163-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
IL-18 (interferon-inducing factor) and IL-12 exhibit a marked synergism in interferon-gamma induction in T cells. Investigations into the mechanism of this synergism have revealed that IL-12 upregulates expression of the IL-18 receptor on cells producing interferon-gamma. Although IL-18 does not induce the development of Th1 cells, it is essential for the effective induction and activation of Th1 cells by IL-12. As for natural killer cells, IL-18 seems to activate them independently of IL-12. Although IL-12 and IL-18 activate both innate and acquired immunity, their excessive production by activated macrophages may induce multiple organ disorders including disruption of the immune system.
引用
收藏
页码:259 / 264
页数:6
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