Hyperintensities and fronto-subcortical atrophy on MRI are substrates of mild cognitive deficits after stroke

被引：36

作者：

Burton, E ^{[1
]}

Ballard, C ^{[1
]}

Stephens, S ^{[1
]}

Kenny, RA ^{[1
]}

Kalaria, R ^{[1
]}

Barber, R ^{[1
]}

O'Brien, J ^{[1
]}

机构：

[1] Newcastle Gen Hosp, Inst Ageing & Hlth, Wolfson Res Ctr, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2003年 / 16卷 / 02期

关键词：

stroke; MRI; voxel-based morphometry; mild cognitive deficits;

D O I：

10.1159/000070684

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aim: The current study determines the MRI correlations of the early neuropsychological post-stroke cognitive deficits. Method. Detailed neuropsychological assessments (attention and working memory) were undertaken in 50 stroke survivors >75 years of age [38 with ageing-associated cognitive decline (AACD)] and 15 age-matched controls. A 1.5-tesla General Electric MRI scanner was used. Standardized visual ratings were undertaken of white matter hyperintensities (WMH). Grey matter volumes were assessed using voxel-based morphometery. Results: Associations were identified between processing speed and executive function and the severity of WMH in key areas. In addition, atrophy in the fronto-subcortical circuits was associated with AACD. Conclusion: Attentional and executive impairments are underpinned by WMH in fronto-striato-thalamo-frontal circuits. Frontal atrophy is identified as a novel substrate of cognitive decline in stroke patients. Copyright (C) 2003 S. Karger AG, Basel.

引用

页码：113 / 118

页数：6

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