Neurogenic amplification of immune complex inflammation

被引：285

作者：

Bozic, CR ^{[1
]}

Lu, B ^{[1
]}

Hopken, UE ^{[1
]}

Gerard, C ^{[1
]}

Gerard, NP ^{[1
]}

机构：

[1] CHILDRENS HOSP,INA SUE PERLMUTTER LAB,BOSTON,MA 02115

来源：

SCIENCE | 1996年 / 273卷 / 5282期

关键词：

D O I：

10.1126/science.273.5282.1722

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The formation of intrapulmonary immune complexes in mice generates a vigorous inflammatory response characterized by microvascular permeability and polymorphonuclear neutrophil influx. Gene-targeted disruption of the substance P receptor (NK-1R) protected the lung from immune complex injury, as did disruption of the C5a anaphylatoxin receptor. Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung.

引用

页码：1722 / 1725

页数：4

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