Neuropeptide Y lowers blood glucose in anaesthetized rats via a Y5 receptor subtype

被引：16

作者：

Bischoff, A ^{[1
]}

Michel, MC ^{[1
]}

机构：

[1] Univ Essen Gesamthsch Klinikum, Med Klin, D-45122 Essen, Germany

来源：

ENDOCRINOLOGY | 1998年 / 139卷 / 06期

关键词：

D O I：

10.1210/en.139.6.3018

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have investigated the receptor subtype mediating effects of neuropeptide Y (NPY) on blood glucose concentrations. In anaesthetized rats a 120 min i.v. infusion of 2 mu g/kg/min NPY lowered blood glucose by 26 mg/dl. This was mimicked by the same dose of peptide YY (PYY), NPY2-36, PYY3-36 and [Leu(31),Pro(34)]NPY but not by NPY13-36, PYY13-36 or rat or human pancreatic polypeptide. The effects of NPY and [Leu(31,)Pro(34)]NPY were not inhibited by 10 mu g/kg/min BIBP 3226. Neither treatment significantly altered plasma insulin concentrations. We conclude that NPY lowers blood glucose concentrations via a Y-5 receptor subtype, i.e. a subtype which has also been implicated in stimulation of food intake.

引用

页码：3018 / 3021

页数：4

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