Aloe-emodin: A review of its pharmacology, toxicity, and pharmacokinetics

被引：303

作者：

Dong, Xiaoxv ^{[1
]}

Zeng, Yawen ^{[1
]}

Liu, Yi ^{[1
]}

You, Longtai ^{[1
]}

Yin, Xingbin ^{[1
]}

Fu, Jing ^{[2
]}

Ni, Jian ^{[3
]}

机构：

[1] Beijing Univ Chinese Med, Sch Chinese Materia Med, Beijing 102488, Peoples R China

[2] Capital Med Univ, Beijing Hosp Tradit Chinese Med, Beijing Inst Tradit Chinese Med, Beijing, Peoples R China

[3] Beijing Univ Chinese Med, Beijing Res Inst Chinese Med, Beijing 100029, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2020年 / 34卷 / 02期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

aloe-emodin; mechanisms; pharmacokinetics; pharmacology; toxicology; N-ACETYLTRANSFERASE ACTIVITY; GASTRIC-CANCER CELLS; INDUCED DNA-DAMAGE; BREAST-CANCER; PHOTODYNAMIC THERAPY; INDUCED APOPTOSIS; ANTIVIRAL ACTIVITY; ESTROGEN-RECEPTOR; GENE-EXPRESSION; DOWN-REGULATION;

D O I：

10.1002/ptr.6532

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Aloe-emodin is a naturally anthraquinone derivative and an active ingredient of Chinese herbs, such as Cassia occidentalis, Rheum palmatum L., Aloe vera, and Polygonum multiflorum Thunb. Emerging evidence suggests that aloe-emodin exhibits many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. These pharmacological properties lay the foundation for the treatment of various diseases, including influenza virus, inflammation, sepsis, Alzheimer's disease, glaucoma, malaria, liver fibrosis, psoriasis, Type 2 diabetes, growth disorders, and several types of cancers. However, an increasing number of published studies have reported adverse effects of aloe-emodin. The primary toxicity among these reports is hepatotoxicity and nephrotoxicity, which are of wide concern worldwide. Pharmacokinetic studies have demonstrated that aloe-emodin has a poor intestinal absorption, short elimination half-life, and low bioavailability. This review aims to provide a comprehensive summary of the pharmacology, toxicity, and pharmacokinetics of aloe-emodin reported to date with an emphasis on its biological properties and mechanisms of action.

引用

页码：270 / 281

页数：12

共 94 条

[1]

Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells [J].