Long-term effects of beta blocker therapy on P-wave duration and dispersion in congestive heart failure patients:: A new effect?

被引：21

作者：

Çamsari, A ^{[1
]}

Pekdemir, H ^{[1
]}

Akkus, MN ^{[1
]}

Yenihan, S ^{[1
]}

Döven, O ^{[1
]}

Cin, VG ^{[1
]}

机构：

[1] Mersin Univ, Fac Med, Dept Cardiol, Mersin, Turkey

来源：

JOURNAL OF ELECTROCARDIOLOGY | 2003年 / 36卷 / 02期

关键词：

heart failure; P-wave duration; P-wave dispersion; beta blocker;

D O I：

10.1054/jelc.2003.50020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atrial fibrillation (AF) is associated with heart failure in approximately 20%-50% of patients with increased morbidity and mortality. P-wave maximum duration (PWM) and P-wave dispersion (PWD) are recent ECG markers and reflect increased risk of AF. The aim of our study was to investigate the long-term effects of metoprolol on atrial conduction abnormalities as estimated by PWM and PWD, which were calculated on 12-derivation surface ECG in heart failure patients. Forty-two NYHA class 3 to 4 patients (23 males, 19 females and aged 52.9 +/- 11.2) were enrolled in the study. At the end of the 6 months, PWM and PWD values were significantly decreased (for PWM: from 115.2 +/- 12.6 to 105.4 +/- 13.5; for PWD: from 39.3 +/- 9.1 to 28.6 +/- 10.5; P < .001 for both). Metoprolol treatment is associated with a decreased duration of PWM and PWD and this may reflect a reduction in the probability of atrial fibrillation in heart failure patients.

引用

页码：111 / 116

页数：6

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